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Objective@#To evaluate measurement acquisition, operability, and measurement agreement of the OA-2000 in cataract eyes with high myopia.@*Methods@#A diagnosis test examined 1 030 eyes of 780 high-myopia cataract patients at the Wuhan Aier Eye Hospital from October 2017 to October 2018.The eyes were examined using the OA-2000, the IOLMaster 500 and the Lenstar-LS900 preoperatively.Measurement acquisition was recorded.The total ophthalmic exam, the duration of patient data entry, the actual measurement process, and the time from intraocular lens power calculation to printout were calculated.Ocular biometric parameters, including anterior chamber depth (ACD), axial length (AL), keratometry for the flattest meridian (Kf), and keratometry for the steepest meridian (Ks) were compared among the devices.This study complied with the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Wuhan Aier Eye Hospital (No.2017IRBKY07).@*Results@#The OA-2000 was capable of obtaining an AL measurement in 94.95% of the eyes, which was significantly higher than the 83.98% and 83.01% measured by the IOLMaster 500 and Lenstar-LS900, respectively (χ2=38.171, 46.208; both at P<0.001). The total ophthalmic exam with the OA-2000 took a significantly shorter time than the Lenstar-LS900 ([109.34±2.22]s vs. [135.64±5.55]s) (P<0.05). Excellent correlations were found for the AL, ACD, Kf, and Ks measurements between the OA-2000 and the IOLMaster 500 (r=0.999, 0.937, 0.996, 0.996; all at P<0.001). Good correlations were also found between the OA-2000 and the Lenstar-LS900 (r=0.999, 0.965, 0.995, 0.996; all at P<0.001). The respective 95% limits of agreement of the OA-2000 and IOLMaster 500, and the OA-2000 and Lenstar-LS900 were -0.19 to 0.20 mm and -0.13 to 0.17 mm for AL; -0.23 to 0.23 mm and -0.18 to 0.16 mm for ACD; -0.48 to 0.47 D and -0.64 to 0.65 D for Kf; -0.49 to 0.47 D and -0.60 to 0.61 D for Ks.@*Conclusions@#In terms of AL, ACD, Kf and Ks in cataractous eyes with high myopia, the OA-2000, IOLMaster 500, and Lenstar-LS900 show excellent correlation and agreement.The OA-2000, a new swept-source OCT-based biometer, outperforms both the IOLMaster 500 and the Lenstar-LS900 in terms of AL measurement acquisition and operability.
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Objective To evaluate measurement acquisition,operability,and measurement agreement of the OA-2000 in cataract eyes with high myopia.Methods A diagnosis test examined 1 030 eyes of 780 high-myopia cataract patients at the Wuhan Aier Eye Hospital from October 2017 to October 2018.The eyes were examined using the OA-2000,the IOLMaster 500 and the Lenstar-LS900 preoperatively.Measurement acquisition was recorded.The total ophthalmic exam,the duration of patient data entry,the actual measurement process,and the time from intraocular lens power calculation to printout were calculated.Ocular biometric parameters,including anterior chamber depth (ACD),axial length (AL),keratometry for the flattest meridian (Kf),and keratometry for the steepest meridian (Ks) were compared among the devices.This study complied with the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Wuhan Aier Eye Hospital (No.2017IRBKY07).Results The OA-2000 was capable of obtaining an AL measurement in 94.95％ of the eyes,which was significantly higher than the 83.98％ and 83.01％ measured by the IOLMaster 500 and Lenstar-LS900,respectively (x2=38.171,46.208;both at P＜0.001).The total ophthalmic exam with the OA-2000 took a significantly shorter time than the Lenstar-LS900 ([109.34±2.22]s vs.[135.64±5.55] s) (P＜0.05).Excellent correlations were found for the AL,ACD,Kf,and Ks measurements between the OA-2000 and the IOLMaster 500 (r =0.999,0.937,0.996,0.996;all at P＜ 0.001).Good correlations were also found between the OA-2000 and the Lenstar-LS900 (r =0.999,0.965,0.995,0.996;all at P＜0.001).The respective 95％ limits of agreement of the OA-2000 and IOLMaster 500,and the OA-2000 and Lenstar-LS900 were-0.19 to 0.20 mm and-0.13 to 0.17 mm for AL;-0.23 to 0.23 mm and-0.18 to 0.16 mm for ACD;-0.48 to 0.47 D and-0.64 to 0.65 D for Kf;-0.49 to 0.47 D and-0.60 to 0.61 D for Ks.Conclusions In terms of AL,ACD,Kf and Ks in cataractous eyes with high myopia,the OA-2000,IOLMaster 500,and Lenstar-LS900 show excellent correlation and agreement.The OA-2000,a new swept-source OCT-based biometer,outperforms both the IOLMaster 500 and the Lenstar-LS900 in terms of AL measurement acquisition and operability.
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Objective To study the efficacy and safety of estradiol and drospirenone tablets (Angeliq)in treatment of menopausal symptoms among postmenopausal Chinese healthy women.Methods Total 244 postmenopausal Chinese healthy women who had moderate to severe hot flushes were randomly assigned for 16 weeks in this randomized multi-center double-blind placebo-controlled study.During the trial.the follow-up visits were conducted at week 4,8,12,16 of treatment and 2 weeks after treatment respectively.Height,weight,vital signs,hot flushes,other relevant menopausal symptoms and vaginal bleeding were observed in each follow-up visit,while the clinical global impression scale Was assessed at 16 weeks as well.Results It showed that hot flushes were reduced significantly more in observation group than that in placebo group ( P＜0.01 ), although both treatments were effective. The absolute values of mean severity index of total hot flushes decreased by - 0. 6± 0. 5 in observation group and - 0. 4 ± 0. 4 in placebo group from baseline respectively, which reached significant difference ( P ＜ 0. 05 ). However, the absolute values of mean severity index of moderate to severe hot flushes decreased by - 0. 6± 0. 8 in observation group and -0. 3± 0.6 in placebo group from baseline respectively, which had no significant difference (P ＞ 0. 05 ).After 16 weeks treatment, it also showed that estradiol and drospirenone had significant better efficacy than placebo on moderate to severe sweating, vaginal dryness and clinical global impression scale (P ＜0. 01 ).During the trial, blood pressure in observation group was stable. The rate of vaginal bleeding in observation group was higher than that in the placebo group, especially during the week 4 to week 8 when 48. 9% (87/178) in observation group and 10. 7% (6/56) in placebo group of patients bled. Although the cumulative amenorrhea rate of observation group was lower than that of placebo group in each cycle (28 days), it increased gradually along with duration of the treatment. The commonest adverse event in observation group was breast tenderness which accounted for 12.0% (22/183 ). The level of serum potassium was in the normal range in observation group mostly. Meanwhile, the other adverse events rate was low. Serious adverse events reported in this trial were assessed as not study drug related or as unlikely study drug related. Conclusion Estradiol and drospirenone tablets which could effectively alleviate menopausal symptoms in postmeuopausal Chinese healthy women is a novel hormone replacement therapy regimen with high safety and efficacy.
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Objective To investigate the influences of active immunotherapy on T helper cell (Th)1/Th2 type cytokines in women with unexplained habitual abortion(UHA) Methods A total of 55 patients with UHA were studied, including 30 cases after active immunotheraphy (AIT) and 25 cases without any therapy(NAIT). Fifteen cases of normal nonpregnant (NNP) women were selected as control group. Supernatants from trophoblast activated peripheral blood mononuclear cells (PBMC) of the three groups were tested by enzyme linked immunosorbent assay (ELISA) for interferon gamma (IFN ?), interleukin 2 (IL 2), IL 4, IL 10. Results (1) The levels of IL 2 and IFN ? in AIT group [(108?37) ng/L and (110 ?52) ng/L, respectively] were lower significantly than those in NAIT group[(223?85) ng/L and (326 ?92) ng/L, respectively]( P 0.05). (2) Twenty six women in AIT group got pregnant, but 8 women experienced pregnancy loss repeatedly whose IL 2?IFN ? levels were higher than those in other 18 women got successful pregnancy and IL 4,IL 10 levels lower than the latter. Conclusions UHA patients have Th1 type immunity to trophoblast and produce high level Th1 type cytokines which probably result in pregnancy loss. Active immunotheraphy could make a shift from Th1 to Th2 immunity, thus favoring the maintenance of pregnancy.
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Objective:To determine the levels of Th1 and Th2 type cytokines in patients with unexplained habitual abortion(UHA).Methods:A total of 54 patients with UHA were studied,including 35 cases of nonpregnant woman which were called UNP group and 19 cases of pregnant women with inevitable abortion(IEA) which were called UIEA group.15 cases of normal pregnant(NP) and 15 cases of normal nonpregnant(NNP) women were selected as control groups.Supernatants from trophoblast-activated peripheral blood mononuclear cells(PBMC) of nonpregnant women groups were tested by enzyme-linked immunosorbent assay(ELISA) for interferon gamma(IFN-?),interleukin-2(IL-2),IL-4,IL-10.Also,these cytokines were tested in the supernatants from PBMC and decidual mononuclear cells(DMC) of pregnant women groups.Results:①The levels of IL-2,IFN-? in trophoblast-activated PBMC supernatants of UNP group were higher and IL-4,IL-10 were lower than those of normal nonpregnant group( P